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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course covers the growth, development and structure of normal bone and joints, the biomechanics of bone connective tissues, and their response to stress, calcium and phosphate homeostasis. Additional topics include regulation by parathyroid hormone and vitamin D, the pathogenesis of metabolic bone diseases and diseases of connective ti
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- health sciences and technology
- musculoskeletal
- bone
- joints
- connective tissue
- biomechanics
- muscle
- metabolic bone diseases
- calcium homeostasis
- phosphate homeostasis
- mineralization
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular Ima
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- health sciences and technology
- human pathology
- disease mechanisms
- cellular pathology
- molecular pathology
- diagnostic tools
- surgical pathology
- diagnostic spectroscopy
- functional imaging
- molecular imaging
- molecular diagnostics
- medicine
- immune system
- transplantation
- diagnosis
- neoplasia
- pathobiology
- pathophysiology
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course is designed to give the student a clear understanding of the pathophysiology of the menstrual cycle, fertilization, implantation, ovum growth development, differentiation and associated abnormalities. Disorders of fetal development including the principles of teratology and the mechanism of normal and abnormal parturition will b
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- health sciences and technology
- clinical case
- physiology
- endocrinology
- pathology
- human reproduction
- quantitative analysis
- reproductive technology
- reproduction
- prenatal diagnosis
- in vitro fertilization
- abortion
- menopause
- contraception
- reproductive biology
- menstrual cycle
- fertility
- impotence
- anatomy
- sexual differentiation
- sex
- pregnancy
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, wit
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- health sciences and technology
- gastroenterology
- anatomy
- physiology
- biochemistry
- biophysics
- bioengineering
- gastrointestinal tract
- pancreas
- liver
- biliary tract system
- gross pathology
- microscopic pathology
- clinical diseases
- molecular
- cellular
- pathophysiological processes
- symptoms
- medical
- health
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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The course will span modern neuroscience from molecular neurobiology to perception and cognition, including the following major topics: anatomy and development of the brain; cell biology of neurons and glia; ion channels and electrical signaling; synaptic transmission, integration, and chemical systems of the brain; sensory systems, from tr
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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The object of the course is to teach students an approach to the study of pharmacologic agents. It is not intended to be a review of the pharmacopoeia. The focus is on the basic principles of biophysics, biochemistry and physiology, as related to the mechanisms of drug action, biodistribution and metabolism. The course consists of lectures
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- health sciences and technology
- health care
- pharmacology
- pharmacologic agents
- medical
- pre-clinical
- biophysics
- biochemistry
- physiology related to drug action
- interaction
- distribution
- metabolism
- toxicity
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clin
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- health sciences and technology
- genetics
- genes
- genetic disorders
- inborn error
- muscular dystrophy
- pku
- phenylketoneuria
- cancer
- tumors
- gene therapy
- disease
- birth defects
- chromosomes
- leukemia
- rnai
- hemophilia
- thalassemia
- deafness
- mutations
- hypertrophic cardiomyopathy
- epigenetics
- rett syndrome
- prenatal diagnosis
- lod scores
- gene linkage
- mitochondrial dis
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation, including molecular structure and assembly of MHC molecules, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immuno
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- health sciences and technology
- immunology
- immune system
- lymphocyte
- antigen
- receptors
- antibody
- t cells
- signal transduction
- immunity
- transplantation
- autoimmunity
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course is a collaborative offering of Sana, Partners in Health, and the Institute for Healthcare Improvement (IHI). The goal of this course is the development of innovations in information systems for developing countries that will (1) translate into improvement in health outcomes, (2) strengthen the existing organizational infrastruct
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Tag(s):
- health sciences and technology
- health informatics
- clinical decision support
- health care management
- public health
- international development
- developing country
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course is a project-based introduction to manipulating and characterizing cells and biological molecules using microfabricated tools. It is designed for first year undergraduate students. In the first half of the term, students perform laboratory exercises designed to introduce (1) the design, manufacture, and use of microfluidic chann
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Tag(s):
- health sciences and technology
- cell manipulation
- microchips
- lithography
- rapid prototyping
- optical imaging of cells
- cell sorting
- microfluidics
- osmosis
- diffusion
- microfabrication
- models of diffusion
- laminar flow
- matlab data analysis
- cell traps
- experimental design
- cytometry techniques
- computer simulation of neural behavior
- casting pdms
- coulter counter
- pla
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of pr
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Tag(s):
- health sciences and technology
- scientific practice
- proposal development
- peer review
- medical research
- human subject review
- animal research
- misconduct
- intellectual property
- grant writing
- career development
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine,
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Tag(s):
- health sciences and technology
- sequence
- structure
- function
- complex biological networks
- quantative modeling
- functional genomics analyses
- algorithms
- statistics
- database
- simulation
- applied medicine
- biotechnology
- drug discovery
- computational biology
- genetic engineering
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course provides a foundation in the following four areas: evolutionary and population genetics; comparative genomics; structural genomics and proteomics; and functional genomics and regulation.
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Tag(s):
- health sciences and technology
- genomics
- quantitative genomics
- comparative genomics
- genes
- genome
- snps
- haplotypes
- sequence alignment
- protein structure
- protein folding
- proteomics
- structural genomics
- functional genomics
- networks
- systems biology
- biological networks
- rna
- dna
- gene expression
- evolutionary genetics
- population genetics
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medici
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Tag(s):
- health sciences and technology
- genomics
- bioengineering
- biological engineering
- personalized medicine
- informatics
- bioinformatics
- human genome
- stem cells
- genetically modified organisms
- biophysics
- bioethics
- society
- bioeconomics
- statistics
- modeling
- datamining
- systems biology
- technology development
- biotechnology
- public policy
- health policy
- business
- econom
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course reviews the key genomic technologies and computational approaches that are driving advances in prognostics, diagnostics, and treatment. Throughout the semester, emphasis will return to issues surrounding the context of genomics in medicine including: what does a physician need to know? what sorts of questions will s/he likely en
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Tag(s):
- health sciences and technology
- genomics
- genomic medicine
- genetics
- genomic measurement
- microarray
- informatics
- bioinformatics
- computational biology
- machine learning
- pharmacogenomics
- complex traits
- individual pharmacology
- cancer diagnostics
- genetic disease
- biomedical
- genomes
- bioethics
- integrative genomics
- genomic technologies
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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Mechanical forces play a decisive role during development of tissues and organs, during remodeling following injury as well as in normal function. A stress field influences cell function primarily through deformation of the extracellular matrix to which cells are attached. Deformed cells express different biosynthetic activity relative to u
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Tag(s):
- health sciences and technology
- cell
- tissue
- organ
- unit cell process
- cell matrix
- tissue structure
- extracellular matrix
- adhesion protein
- integrin
- cell force
- cell contraction
- healing
- skin
- scar
- tendon
- ligament
- cartilage
- bone
- collagen
- muscle
- nerve
- implant
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