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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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The mammalian brain easily outperforms any computer. It adapts and changes constantly. Most importantly, the brain enables us to continuously learn and remember. What are the molecular mechanisms that lead to learning and memory? What are the cellular roles that activity-regulated gene products play to implement changes in the brain?How do
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- biology
- learning
- memory
- genes
- genetic expression
- nervous system
- neuroscience
- neuronal plasticity
- synapse formation
- synaptic growth
- synaptic stabilization
- synaptic transmission
- axonal outgrowth
- dendritic outgrowth
- neural circuit formation
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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Watson and Crick noted that the size of a viral genome was insufficient to encode a protein large enough to encapsidate it and reasoned, therefore that a virus shell must be composed of multiple, but identical subunits. Today, high resolution structures of virus capsids reveal the basis of this genetic economy as a highly symmetrical struct
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- biology
- viruses
- virus structure
- virus assembly
- virus shell
- virus genome
- capsids
- capsid assembly
- tem
- transmission electron microscopy
- nano-life
- nano-structures
- virus symmetry
- icosahedral virus
- electron cryotomography
- nucleic acid packaging
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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Regenerative medicine involves the repair and regeneration of tissues for therapeutic purposes, such as replacing bone marrow in leukemia, cartilage in osteoarthritis or cells of the heart after a heart attack. In this course, we will explore basic mechanisms of how cells differentiate into specific tissues in response to a variety of biolo
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.
This seminar provides a deeper understanding of the post-t
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Tag(s):
- biology
- ubiquitination
- ubiquitin
- proteasome
- post-translational mechanisms
- ubiquitin-conjugation system
- neurodegenerative diseases
- immune response
- cell cycle regulation
- apoptosis
- signal transduction pathways
- tumorigenesis
- protein degradation
- endoplasmic reticulum associated degradation pathway
- ligases
- translocated proteins
- misfolded p
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen in
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- biology
- hiv
- mycobacterium tuberculosis
- malaria
- influenza
- immune system
- pathogens
- viruses
- bacteria
- parasites
- microbes
- phagocytosis
- ubiquitin/proteasome pathway
- mhc i/ii antigen presentation
- salmonella
- pathogen-associated molecular patterns
- pamp
- toll-like receptors
- tlr
- vaccinia virus
- proteasome
- ubiquitin; deubiquinating enzymes
- d
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as ge
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- biology
- molecularly targeted therapy
- blood disorders
- chronic myelogenous leukemia
- cml
- gleevec
- chromosomal translocation
- stem cells
- blood cells
- hematopoiesis
- hematopoieteic stem cell
- genetic disorder
- leukemia
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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One summer in the 1960s a young Japanese researcher, with the help of a few high school students, chopped up ten thousand jellyfish. As a by-product of this harvest, they isolated a green fluorescent protein (GFP). Since then, GFP has triggered a revolution in our understanding of gene expression and signaling in live cells. In this seminar
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Tag(s):
- biology
- green fluorescent protein
- fluorescent protein engineering
- photoconversion
- fluorescent protein variants
- fluorescent microscopy facility
- quantitative fluorescent imaging
- ultra-sensitive fluorescent imaging
- high-throughput analysis
- fluorescent imaging in living organisms
- phycoerythrin
- phytochrome
- jellyfish
- red fluorescent protein
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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Cellular responses to DNA damage constitute one of the most important fields in cancer biology. In this class we will analyze classical and recent papers from the primary research literature to gain a profound understand of cell cycle regulation and DNA damage checkpoints that act as powerful emergency brakes to prevent cancer.
This course
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Tag(s):
- biology
- dna
- damage checkpoints
- cancer
- cells
- human cells
- exogenous
- endogenous
- checkpoints
- gene
- signaling
- cancer biology
- cancer prevention
- primary sources
- discussion
- dna damage
- molecular
- enzyme
- cell cycle
- extracellular cues
- growth factors
- cdk regulation
- cyclin-dependent kinase
- p53
- tumor suppressor
- apoptosis
- mdc1
- h2ax
- rad50
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.
In 1971, President Nixon declared the "War on Cancer," but
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Tag(s):
- biology
- cancer
- tumor
- metastasis
- genetic analysis
- cancer biology
- model organisms
- genetic pathways
- uncontrolled growth
- tumor suppressor genes
- oncogenes
- tumor initiation
- cell cycle
- chromosomal aberration
- apoptosis
- cell death
- signal transduction pathways
- proto-oncogene
- mutation
- dna mismatch repair
- telomeres
- mouse models
- tissue spec
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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In this course we will explore the new emerging field of pathogen-induced chronic diseases. Work in this field has redefined the causes of some major disorders, such as ulcers. By reading the primary research literature we will learn about the molecular mechanisms through which pathogens cause disease. The diseases that we cover will be int
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Tag(s):
- biology
- seminar
- literature review
- cancer
- vaccine
- antibiotic
- chronic
- atherosclerosis
- diabetes
- human papilloma virus
- hpv
- helicobacter pylori
- epstein-barr
- treatment strategies
- laboratory techniques
- lab
- herpes
- microbes
- infection
- health
- epstein-barr
- cervical cancer
- cirrhosis
- multiple sclerosis
- hepatitis
- hepatocellular carcinoma
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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How does a regenerating animal "know" what's missing? How are stem cells or differentiated cells used to create new tissues during regeneration? In this class we will take a comparative approach to explore this fascinating problem by critically examining classic and modern scientific literature about the developmental and molecular biology
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Tag(s):
- biology
- regeneration
- blastema
- embryo
- progenitor
- stem cells
- differentiation
- dedifferentiation
- hydra
- morphallaxis
- limb
- organ
- zebrafish
- homeostasis
- self-renewal
- regenerative medicine
- differentitate
- regulate
- salamander
- catenin
- newt
- liver
- pluriptent
- fibroblast
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answ
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- biology
- allergies
- hypertension
- depression
- obesity
- central nervous system disorders
- g-protein coupled receptors
- gpcr
- cell-surface receptors
- george wald
- vision
- chromophore
- transducin
- metarhodopsin ii
- homodimers
- heterodimers
- retinitis pigmentosa
- night blindness
- dopamine
- antihistamines
- claviceps purpurea
- human chemokine receptor 5
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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The primary role of mitochondria is to produce 90% of a cell's energy in the form of ATP through a process called oxidative phosphorylation. A variety of clinical disorders have been shown to include "mitochondrial dysfunction," which loosely refers to defective oxidative phosphorylation and usually coincides with the occurrence of excess R
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Tag(s):
- biology
- mitochondria
- human disease
- atp
- oxidative phosphorylation
- mitochondrial genome
- reactive oxygen species (ros)
- mitochondrial dysfunction
- oxidative stress
- 8-oxoguanine
- 8-oxog
- mtdna
- ogg1
- oxoguanine glycosylase
- mitochondrial dna polymerase
- alzheimer’s disease
- parkinson’s disease
- y955c
- mitochondrial dna depletion syndromes
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells?
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Tag(s):
- biology
- blueprint of life
- transcription
- stem cells
- differentiation
- human tissues
- tissue regeneration
- human disease
- rna and protein expression patterns
- transcriptional regulation
- specialized gene expression programs
- genome
- multipotent
- terminally differentiated
- pluripotency
- master regulators
- chromatin regulators
- developmental defects
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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A millennial challenge in biology is to decipher how vast arrays of molecular interactions inside the cell work in concert to produce a cellular function. Systems biology, a new interdisciplinary field of science, brings together biologists and physicists to tackle this grand challenge through quantitative experiments and models. In this co
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Tag(s):
- biology
- systems biology
- synthetic biology
- cell
- cellular functions
- biological systems
- artificial gene networks
- molecular interactions
- molecular biology
- genes
- rna
- proteins
- macromolecules
- intracellular biochemical interactions
- extracellular molecules
- gene expression
- stochastic gene expression
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Published by: Massachusetts Institute of Technology | Language: English
Published by: Massachusetts Institute of Technology | Language: English
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In this seminar, we will discuss some of the main themes that have arisen in the field of systems biology, including the concepts of robustness, stochastic cell-to-cell variability, and the evolution of molecular interactions within complex networks.
This course is one of many Advanced Undergraduate Seminars offered by the Biology Departmen
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Tag(s):
- biology
- systems biology
- synthetic networks
- noise
- gene expression
- oscillators
- pcr
- stochastic
- robustness
- biological networks
- chemotaxis
- circadian